Fig. 1

Development and setup of the physical simulator.  A Design of the generic skull with case-specific housing and case-specific aneurysm model. B Digital rendering of the interlocking system housing-skull , with the printed aneurysm in position in the housing. C Physical realization of the housing with the printed aneurysm mounted in place and connected to extension lines. D Full laboratory setup of physical simulator comprising surgical microscope , surgical tools (clips , clip applicators , forceps , saline solution , fluorophore for ICG-VA , syringes) , physical simulator connected to voltage-controlled perfusion system